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| H | Tepatitlán | - | Loros UCOL | 0:2 | ||
| R | Loros UCOL | - | Tepatitlán | 1:1 | ||
| H: 26.04.2018 00:00 | R: 28.04.2018 23:00 | Sieger: Loros UCOL | ||||
| H | Inter Playa | - | Club Irapuato | 2:2 | ||
| R | Club Irapuato | - | Inter Playa | 3:0 | ||
| H: 26.04.2018 02:00 | R: 29.04.2018 02:00 | Sieger: Club Irapuato | ||||
| H | Alacranes de Durango | - | Reboceros de La Piedad | 0:1 | ||
| R | Reboceros de La Piedad | - | Alacranes de Durango | 1:0 | ||
| H: 26.04.2018 03:00 | R: 29.04.2018 03:00 | Sieger: Reboceros de La Piedad | ||||
| H | Atlético Reynosa | - | Tuxtla FC | 1:1 | ||
| R | Tuxtla FC | - | Atlético Reynosa | 1:2 | ||
| H: 27.04.2018 02:30 | R: 29.04.2018 23:00 | Sieger: Atlético Reynosa | ||||
