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| H | Deportivo Guadalajara | - | UANL Tigres | 3:1 (1:0) | ||
| R | UANL Tigres | - | Deportivo Guadalajara | 1:1 (0:0) | ||
| H: 05.05.2011 02:00 | R: 08.05.2011 02:00 | Sieger: Deportivo Guadalajara | ||||
| H | Cruz Azul | - | Atlante | 2:1 (1:1) | ||
| R | Atlante | - | Cruz Azul | 0:0 (0:0) | ||
| H: 05.05.2011 04:00 | R: 08.05.2011 04:00 | Sieger: Cruz Azul | ||||
| H | CF Monterrey | - | Pumas UNAM | 3:1 (2:0) | ||
| R | Pumas UNAM | - | CF Monterrey | 2:0 (1:0) | ||
| H: 06.05.2011 02:00 | R: 08.05.2011 19:00 | Sieger: Pumas UNAM | ||||
| H | CF América | - | Monarcas Morelia | 1:2 (0:1) | ||
| R | Monarcas Morelia | - | CF América | 3:2 (1:1) | ||
| H: 06.05.2011 04:00 | R: 09.05.2011 03:00 | Sieger: Monarcas Morelia | ||||
