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| H | CF América | - | Club León | 4:1 (3:1) | ||
| R | Club León | - | CF América | 2:1 (1:0) | ||
| H: 26.11.2015 02:00 | R: 29.11.2015 03:06 | Sieger: CF América | ||||
| H | UANL Tigres | - | Chiapas FC | 2:1 (1:0) | ||
| R | Chiapas FC | - | UANL Tigres | 0:1 (0:1) | ||
| H: 26.11.2015 04:00 | R: 29.11.2015 01:00 | Sieger: UANL Tigres | ||||
| H | CD Veracruz | - | Pumas UNAM | 0:1 (0:1) | ||
| R | Pumas UNAM | - | CD Veracruz | 1:0 (1:0) | ||
| H: 29.11.2015 19:00 | R: 29.11.2015 19:00 | Sieger: Pumas UNAM | ||||
| H | Puebla FC | - | Deportivo Toluca | 0:1 (0:0) | ||
| R | Deportivo Toluca | - | Puebla FC | 1:0 (0:0) | ||
| H: 30.11.2015 00:00 | R: 30.11.2015 00:00 | Sieger: Deportivo Toluca | ||||
