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| 25.03.2022 | 21:00 | FC Dordrecht | - | ADO Den Haag | 3:1 (1:1) | |
| 21:00 | FC Eindhoven | - | De Graafschap | 1:2 (0:2) | ||
| 26.03.2022 | 16:30 | FC Den Bosch | - | VVV-Venlo | 0:0 (0:0) | |
| 18:45 | SBV Excelsior | - | Helmond Sport | 3:0 (1:0) | ||
| 27.03.2022 | 14:30 | MVV | - | Almere City FC | 0:3 (0:2) | |
| 16:45 | FC Emmen | - | Telstar | 2:1 (1:1) | ||
| 04.04.2022 | 20:00 | Jong Ajax | - | TOP Oss | 4:1 (3:0) | |
| 20:00 | AZ Alkmaar (J) | - | Roda JC Kerkrade | 0:1 (0:0) | ||
| 20:00 | FC Utrecht (J) | - | NAC Breda | 1:0 (0:0) | ||
| 20:00 | Jong PSV | - | FC Volendam | 2:2 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Emmen | 32 | 22 | 4 | 6 | 54:22 | 32 | 70 |
| 2 |
|
FC Volendam | 32 | 18 | 11 | 3 | 68:43 | 25 | 65 |
| 3 |
|
SBV Excelsior | 32 | 19 | 5 | 8 | 73:42 | 31 | 62 |
| 4 |
|
FC Eindhoven | 32 | 17 | 7 | 8 | 60:37 | 23 | 58 |
| 5 |
|
Jong Ajax | 32 | 17 | 6 | 9 | 72:55 | 17 | 57 |
| 6 |
|
Roda JC Kerkrade | 32 | 15 | 11 | 6 | 64:38 | 26 | 56 |
| 7 |
|
ADO Den Haag | 32 | 18 | 6 | 8 | 66:48 | 18 | 54 |
| 8 |
|
De Graafschap | 32 | 14 | 8 | 10 | 43:35 | 8 | 50 |
| 9 |
|
NAC Breda | 32 | 13 | 9 | 10 | 49:39 | 10 | 48 |
| 10 |
|
VVV-Venlo | 32 | 12 | 5 | 15 | 40:44 | -4 | 41 |
| 11 |
|
Jong PSV | 32 | 10 | 8 | 14 | 54:54 | 0 | 38 |
| 12 |
|
Almere City FC | 32 | 9 | 8 | 15 | 49:58 | -9 | 35 |
| 13 |
|
AZ Alkmaar (J) | 32 | 10 | 5 | 17 | 31:42 | -11 | 35 |
| 14 |
|
FC Den Bosch | 32 | 10 | 4 | 18 | 33:57 | -24 | 34 |
| 15 |
|
TOP Oss | 32 | 8 | 8 | 16 | 40:53 | -13 | 32 |
| 16 |
|
FC Dordrecht | 32 | 8 | 8 | 16 | 47:68 | -21 | 32 |
| 17 |
|
Telstar | 32 | 7 | 11 | 14 | 36:60 | -24 | 32 |
| 18 |
|
FC Utrecht (J) | 32 | 9 | 4 | 19 | 32:57 | -25 | 31 |
| 19 |
|
MVV | 32 | 9 | 2 | 21 | 34:67 | -33 | 29 |
| 20 |
|
Helmond Sport | 32 | 7 | 6 | 19 | 32:58 | -26 | 24 |
| Aufstieg | |
| Playoffs | |
| Playoffs |
|
# ADO Den Haag: -6 P. # Helmond Sport: -3 P. |
