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| 21.08.2012 | 17:00 | FK Astibo | - | 11 Oktomvri | 0:3 | |
| 22.08.2012 | FK Plačkovica | - | KF Shkëndija 79 | 0:3 Wert. | ||
| 17:00 | FK Viktorija | - | FK Rabotnički | 5:3 i.E. | ||
| 17:00 | FK Karaorman | - | Metalurg Skopje | 1:2 (0:1) | ||
| 17:00 | FK Madzari 92 | - | FK Drita | 0:1 | ||
| 17:00 | FK Novaci 2005 | - | FK Renova | 1:2 | ||
| 17:00 | Babi Štip | - | Napredok Kičevo | 1:0 (1:0) | ||
| 17:00 | Lokomotiva Skopje | - | FK Miravci | 4:2 (1:1, 2:2) i.E. | ||
| 17:00 | KF Rufeja | - | Vardar Skopje | 0:2 | ||
| 17:00 | FK Belasica | - | Sileks Kratovo | 1:3 | ||
| 17:00 | Babuna Martolci | - | FK Turnovo | 0:4 | ||
| 17:00 | FK Ljuboten | - | FK Gorno Lisiče | 0:5 | ||
| 17:00 | FK Ohrid | - | FK Teteks | 2:7 (1:3) | ||
| 17:00 | KF Bashkimi | - | GFK Tikvesh | 5:4 i.E. | ||
| 17:00 | KF Gostivari | - | FK Bregalnica Štip | 1:3 (0:0, 0:0) i.E. | ||
| 17:00 | Slavej Mesheishta | - | FK Pelister | 0:6 |
