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| 14.08.2021 | 22:00 | Red Bull Bragantino | - | Juventude - RS | 1:2 (1:0) | |
| 15.08.2021 | 00:00 | Atlético Mineiro | - | Palmeiras | 2:0 (1:0) | |
| 02:00 | São Paulo FC | - | Grêmio Porto Alegre | 2:1 (1:1) | ||
| 21:00 | Corinthians SP | - | Ceará - CE | 3:1 (2:0) | ||
| 21:00 | Flamengo RJ | - | Sport Recife - PE | 2:0 (1:0) | ||
| 23:15 | Bahia - BA | - | Atlético Goianiense | 1:2 (1:0) | ||
| 23:15 | Cuiabá - MT | - | Athletico Paranaense | 1:0 (0:0) | ||
| 23:15 | Fortaleza | - | Santos FC | 1:1 (1:1) | ||
| 16.08.2021 | 01:30 | Internacional | - | Fluminense RJ | 4:2 (1:1) | |
| 17.08.2021 | 01:00 | Chapecoense | - | América - MG | 1:1 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Atlético Mineiro | 16 | 12 | 1 | 3 | 25:11 | 14 | 37 |
| 2 |
|
Palmeiras | 16 | 10 | 2 | 4 | 27:17 | 10 | 32 |
| 3 |
|
Fortaleza | 16 | 9 | 4 | 3 | 26:15 | 11 | 31 |
| 4 |
|
Flamengo RJ | 16 | 9 | 2 | 5 | 31:19 | 12 | 29 |
| 5 |
|
Red Bull Bragantino | 16 | 7 | 7 | 2 | 26:18 | 8 | 28 |
| 6 |
|
Athletico Paranaense | 16 | 7 | 3 | 6 | 24:20 | 4 | 24 |
| 7 |
|
Atlético Goianiense | 16 | 6 | 5 | 5 | 14:16 | -2 | 23 |
| 8 |
|
Ceará - CE | 16 | 5 | 8 | 3 | 18:16 | 2 | 23 |
| 9 |
|
Internacional | 16 | 5 | 6 | 5 | 20:20 | 0 | 21 |
| 10 |
|
Santos FC | 16 | 5 | 6 | 5 | 17:17 | 0 | 21 |
| 11 |
|
Corinthians SP | 16 | 5 | 6 | 5 | 15:15 | 0 | 21 |
| 12 |
|
Juventude - RS | 16 | 5 | 5 | 6 | 13:18 | -5 | 20 |
| 13 |
|
Bahia - BA | 16 | 5 | 3 | 8 | 20:26 | -6 | 18 |
| 14 |
|
Fluminense RJ | 16 | 4 | 6 | 6 | 13:18 | -5 | 18 |
| 15 |
|
São Paulo FC | 16 | 4 | 6 | 6 | 13:19 | -6 | 18 |
| 16 |
|
Cuiabá - MT | 16 | 3 | 8 | 5 | 15:18 | -3 | 17 |
| 17 |
|
Sport Recife - PE | 16 | 3 | 6 | 7 | 8:13 | -5 | 15 |
| 18 |
|
América - MG | 16 | 3 | 6 | 7 | 13:20 | -7 | 15 |
| 19 |
|
Grêmio Porto Alegre | 16 | 3 | 5 | 8 | 12:19 | -7 | 14 |
| 20 |
|
Chapecoense | 16 | 0 | 5 | 11 | 13:28 | -15 | 5 |
| Copa Libertadores | |
| Qualifikation | |
| Copa Sudamericana | |
| Abstieg |
