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| 25.02.2006 | 17:30 | Atlético Malagueño | - | Real Valladolid | 2:1 (2:0) | |
| 18:30 | Albacete | - | Levante UD | 1:1 (1:1) | ||
| 18:30 | UD Almería | - | CD Tenerife | 2:0 (1:0) | ||
| 18:30 | Real Madrid Castilla | - | Sporting Gijón | 1:1 (0:1) | ||
| 18:30 | Recreativo Huelva | - | SD Eibar | 0:0 (0:0) | ||
| 26.02.2006 | 12:00 | Gimnàstic de Tarragona | - | Lorca Deportiva | 2:0 (1:0) | |
| 17:00 | Real Murcia | - | Polideportivo Ejido | 0:0 (0:0) | ||
| 17:00 | Elche CF | - | Racing Ferrol | 1:0 (0:0) | ||
| 17:30 | CD Castellón | - | Ciudad de Murcia | 1:2 (1:0) | ||
| 17:30 | Xerez CD | - | UE Lleida | 0:1 (0:0) | ||
| 22.03.2006 | 20:30 | CD Numancia | - | Hércules CF | 1:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Recreativo Huelva | 26 | 13 | 9 | 4 | 35:20 | 15 | 48 |
| 2 |
|
Xerez CD | 26 | 12 | 9 | 5 | 41:27 | 14 | 45 |
| 3 |
|
Levante UD | 26 | 12 | 9 | 5 | 35:25 | 10 | 45 |
| 4 |
|
Gimnàstic de Tarragona | 26 | 14 | 3 | 9 | 28:25 | 3 | 45 |
| 5 |
|
Lorca Deportiva | 26 | 12 | 7 | 7 | 36:23 | 13 | 43 |
| 6 |
|
UD Almería | 26 | 12 | 6 | 8 | 32:23 | 9 | 42 |
| 7 |
|
Ciudad de Murcia | 26 | 10 | 8 | 8 | 31:30 | 1 | 38 |
| 8 |
|
Albacete | 26 | 10 | 7 | 9 | 27:33 | -6 | 37 |
| 9 |
|
Real Madrid Castilla | 26 | 10 | 6 | 10 | 35:29 | 6 | 36 |
| 10 |
|
CD Numancia | 26 | 9 | 9 | 8 | 25:32 | -7 | 36 |
| 11 |
|
Real Valladolid | 26 | 8 | 11 | 7 | 35:31 | 4 | 35 |
| 12 |
|
Elche CF | 26 | 9 | 7 | 10 | 32:37 | -5 | 34 |
| 13 |
|
Sporting Gijón | 26 | 7 | 12 | 7 | 26:22 | 4 | 33 |
| 14 |
|
Real Murcia | 26 | 8 | 9 | 9 | 23:23 | 0 | 33 |
| 15 |
|
UE Lleida | 26 | 9 | 5 | 12 | 26:27 | -1 | 32 |
| 16 |
|
Hércules CF | 26 | 7 | 9 | 10 | 26:31 | -5 | 30 |
| 17 |
|
Polideportivo Ejido | 26 | 8 | 6 | 12 | 27:33 | -6 | 30 |
| 18 |
|
CD Tenerife | 26 | 8 | 6 | 12 | 32:39 | -7 | 30 |
| 19 |
|
Racing Ferrol | 26 | 5 | 11 | 10 | 29:36 | -7 | 26 |
| 20 |
|
CD Castellón | 26 | 6 | 7 | 13 | 24:35 | -11 | 25 |
| 21 |
|
SD Eibar | 26 | 4 | 12 | 10 | 18:28 | -10 | 24 |
| 22 |
|
Atlético Malagueño | 26 | 5 | 8 | 13 | 19:33 | -14 | 23 |
