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| 10.04.2022 | 15:00 | Cascina | - | SSD Tiferno Lerchi | 1:0 | |
| 15:00 | Foligno Calcio | - | Scandicci Calcio | 1:1 | ||
| 15:00 | Follonica Gavorrano | - | ASD Cannara | 5:0 | ||
| 15:00 | Montespaccato | - | Virtus Flaminia | 0:2 | ||
| 15:00 | FC Rieti | - | Badesse Calcio | 2:0 | ||
| 15:00 | San Donato Tavarnelle | - | Pro Livorno Sorgenti | 5:1 | ||
| 15:00 | AC Sangiovannese | - | US Pianese | 1:0 | ||
| 15:00 | SC Trestina | - | Unipomezia Virtus | 2:0 | ||
| 15:00 | US Arezzo | - | US Poggibonsi | 2:1 |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
San Donato Tavarnelle | 28 | 21 | 3 | 4 | 78:27 | 51 | 66 |
| 2 |
|
US Poggibonsi | 28 | 19 | 4 | 5 | 45:22 | 23 | 61 |
| 3 |
|
Follonica Gavorrano | 28 | 14 | 9 | 5 | 50:23 | 27 | 51 |
| 4 |
|
US Arezzo | 28 | 14 | 9 | 5 | 51:38 | 13 | 51 |
| 5 |
|
SC Trestina | 28 | 12 | 10 | 6 | 42:27 | 15 | 46 |
| 6 |
|
Badesse Calcio | 28 | 12 | 8 | 8 | 37:35 | 2 | 44 |
| 7 |
|
US Pianese | 28 | 12 | 7 | 9 | 44:36 | 8 | 43 |
| 8 |
|
Virtus Flaminia | 28 | 11 | 7 | 10 | 42:41 | 1 | 40 |
| 9 |
|
SSD Tiferno Lerchi | 28 | 10 | 10 | 8 | 32:34 | -2 | 40 |
| 10 |
|
Scandicci Calcio | 28 | 9 | 8 | 11 | 30:37 | -7 | 35 |
| 11 |
|
Montespaccato | 28 | 9 | 7 | 12 | 34:36 | -2 | 34 |
| 12 |
|
AC Sangiovannese | 28 | 7 | 11 | 10 | 31:35 | -4 | 32 |
| 13 |
|
Cascina | 28 | 7 | 7 | 14 | 25:34 | -9 | 28 |
| 14 |
|
FC Rieti | 28 | 7 | 7 | 14 | 32:48 | -16 | 28 |
| 15 |
|
Foligno Calcio | 28 | 7 | 7 | 14 | 37:55 | -18 | 28 |
| 16 |
|
Unipomezia Virtus | 28 | 7 | 6 | 15 | 32:52 | -20 | 27 |
| 17 |
|
ASD Cannara | 28 | 4 | 7 | 17 | 21:43 | -22 | 19 |
| 18 |
|
Pro Livorno Sorgenti | 28 | 4 | 5 | 19 | 27:67 | -40 | 17 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
