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| 01.05.2022 | 15:00 | Cascina | - | FC Rieti | 2:1 | |
| 15:00 | Foligno Calcio | - | Badesse Calcio | 3:3 | ||
| 15:00 | Follonica Gavorrano | - | Unipomezia Virtus | 2:0 | ||
| 15:00 | Montespaccato | - | SC Trestina | 3:1 | ||
| 15:00 | Pro Livorno Sorgenti | - | US Poggibonsi | 0:4 | ||
| 15:00 | San Donato Tavarnelle | - | Scandicci Calcio | 1:0 | ||
| 15:00 | AC Sangiovannese | - | Virtus Flaminia | 2:1 | ||
| 15:00 | SSD Tiferno Lerchi | - | US Pianese | 0:3 | ||
| 15:00 | US Arezzo | - | ASD Cannara | 2:1 |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
San Donato Tavarnelle | 32 | 24 | 3 | 5 | 84:30 | 54 | 75 |
| 2 |
|
US Poggibonsi | 32 | 22 | 4 | 6 | 55:25 | 30 | 70 |
| 3 |
|
US Arezzo | 32 | 17 | 10 | 5 | 62:42 | 20 | 61 |
| 4 |
|
Follonica Gavorrano | 32 | 16 | 9 | 7 | 54:28 | 26 | 57 |
| 5 |
|
US Pianese | 32 | 15 | 8 | 9 | 53:38 | 15 | 53 |
| 6 |
|
Badesse Calcio | 32 | 14 | 9 | 9 | 45:41 | 4 | 51 |
| 7 |
|
SC Trestina | 32 | 12 | 10 | 10 | 45:36 | 9 | 46 |
| 8 |
|
Virtus Flaminia | 32 | 13 | 7 | 12 | 48:46 | 2 | 46 |
| 9 |
|
SSD Tiferno Lerchi | 32 | 10 | 10 | 12 | 33:45 | -12 | 40 |
| 10 |
|
Montespaccato | 32 | 11 | 7 | 14 | 40:41 | -1 | 40 |
| 11 |
|
Cascina | 32 | 11 | 7 | 14 | 35:36 | -1 | 40 |
| 12 |
|
Scandicci Calcio | 32 | 10 | 9 | 13 | 32:40 | -8 | 39 |
| 13 |
|
AC Sangiovannese | 32 | 8 | 13 | 11 | 35:39 | -4 | 37 |
| 14 |
|
FC Rieti | 32 | 9 | 7 | 16 | 37:55 | -18 | 34 |
| 15 |
|
Foligno Calcio | 32 | 8 | 8 | 16 | 44:62 | -18 | 32 |
| 16 |
|
Unipomezia Virtus | 32 | 8 | 6 | 18 | 37:62 | -25 | 30 |
| 17 |
|
ASD Cannara | 32 | 5 | 8 | 19 | 26:50 | -24 | 23 |
| 18 |
|
Pro Livorno Sorgenti | 32 | 5 | 5 | 22 | 29:78 | -49 | 20 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
