| 1. Spieltag | 21.08.2021 | AS Cittadella | - | L.R. Vicenza | 1:0 |  |
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| 2. Spieltag | 29.08.2021 | AS Cittadella | - | FC Crotone | 4:2 |  |
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| 3. Spieltag | 12.09.2021 | US Cremonese | - | AS Cittadella | 2:0 | |
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| 4. Spieltag | 18.09.2021 | AS Cittadella | - | Pordenone Calcio | 1:0 | ||||
| 5. Spieltag | 21.09.2021 | Benevento Calcio | - | AS Cittadella | 4:1 | ||||
| 6. Spieltag | 25.09.2021 | AS Cittadella | - | US Lecce | 1:2 | |
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| 7. Spieltag | 02.10.2021 | Frosinone Calcio | - | AS Cittadella | 0:1 | |
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| 8. Spieltag | 17.10.2021 | AS Cittadella | - | SPAL 2013 Ferrara | 0:0 | ||||
| 9. Spieltag | 23.10.2021 | AC Monza | - | AS Cittadella | 1:0 | ||||
| 10. Spieltag | 28.10.2021 | AS Cittadella | - | Parma Calcio 1913 | 1:2 | ||||
| 11. Spieltag | 01.11.2021 | Reggina 1914 | - | AS Cittadella | 0:1 | ||||
| 12. Spieltag | 07.11.2021 | AS Cittadella | - | Pisa SC | 2:0 | ||||
| 13. Spieltag | 20.11.2021 | Ternana Calcio | - | AS Cittadella | 1:1 | |
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| 15. Spieltag | 01.12.2021 | AS Cittadella | - | Como 1907 | 2:2 | |
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| 16. Spieltag | 05.12.2021 | US Alessandria 1912 | - | AS Cittadella | 0:1 | |
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| 17. Spieltag | 11.12.2021 | AS Cittadella | - | Ascoli Calcio | 2:0 | ||||
| 18. Spieltag | 19.12.2021 | Brescia Calcio | - | AS Cittadella | 1:1 | |
Italien