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| 30.10.2018 | 18:30 | PSV Eindhoven | - | RKC Waalwijk | 2:3 (1:1, 2:2) n.V. | |
| 19:00 | Amsterdamsche FC | - | TOP Oss | 1:0 (0:0) | ||
| 19:45 | Kozakken Boys | - | Almere City FC | 2:1 (1:0) | ||
| 19:45 | FC Twente | - | VV Noordwijk | 4:2 (3:1) | ||
| 19:45 | SC Cambuur | - | Koninklijke HFC | 2:1 (1:0) | ||
| 19:45 | SV Urk | - | Roda JC Kerkrade | 0:1 (0:0) | ||
| 20:45 | De Graafschap | - | PEC Zwolle | 2:5 (0:3) | ||
| 31.10.2018 | 18:30 | Heracles Almelo | - | Vitesse | 0:2 (0:1) | |
| 19:45 | Willem II | - | SV Spakenburg | 5:0 (2:0) | ||
| 19:45 | FC Utrecht | - | ASWH Ido-Ambacht | 5:1 (2:1) | ||
| 19:45 | FC Emmen | - | ODIN '59 | 1:3 (1:1) | ||
| 19:45 | AZ Alkmaar | - | VVV-Venlo | 2:0 (0:0) | ||
| 19:45 | RKSV Groene Ster | - | sc Heerenveen | 1:3 (1:0) | ||
| 20:45 | AFC Ajax | - | Go Ahead Eagles | 3:0 (2:0) | ||
| 01.11.2018 | 18:30 | NEC Nijmegen | - | Fortuna Sittard | 2:3 (2:1) | |
| 20:45 | Feyenoord | - | ADO Den Haag | 5:1 (2:1) |
