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| 17.12.2019 | 18:30 | FC Twente | - | Go Ahead Eagles | 2:5 (1:2) | |
| 19:45 | IJsselmeervogels | - | SteDoCo | 1:0 (1:0) | ||
| 19:45 | sc Heerenveen | - | Roda JC Kerkrade | 2:0 (1:0) | ||
| 19:45 | Vitesse | - | ODIN '59 | 4:0 (4:0) | ||
| 19:45 | VV Katwijk | - | TOP Oss | 3:4 (0:0, 0:0, 0:0) i.E. | ||
| 19:45 | SBV Excelsior | - | FC Eindhoven | 0:2 (0:0) | ||
| 20:45 | Fortuna Sittard | - | PEC Zwolle | 3:0 (2:0) | ||
| 18.12.2019 | 18:30 | Telstar | - | AFC Ajax | 3:4 (1:2) | |
| 19:45 | Heracles Almelo | - | FC Dordrecht | 3:0 (1:0) | ||
| 19:45 | OFC Oostzaan | - | SV Spakenburg | 4:5 (0:0, 0:0, 0:0) i.E. | ||
| 19:45 | AZ Alkmaar | - | RKSV Groene Ster | 3:0 (0:0) | ||
| 19:45 | Willem II | - | Sparta Rotterdam | 3:0 (3:0) | ||
| 19:45 | Sparta Nijkerk | - | NAC Breda | 0:1 (0:0, 0:0) n.V. | ||
| 20:45 | GVVV | - | PSV Eindhoven | 1:2 (0:1, 1:1) n.V. | ||
| 19.12.2019 | 18:30 | FC Groningen | - | FC Utrecht | 0:1 (0:0) | |
| 20:45 | SC Cambuur | - | Feyenoord | 1:2 (0:0) |
