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| 08.02.2022 | 14:30 | AZ Alkmaar | - | Villarreal CF | 4:3 (2:1, 3:3) i.E. | |
| 16:00 | Rangers FC | - | Sevilla FC | 0:1 (0:0) | ||
| 16:30 | MŠK Žilina | - | Inter | 3:1 (1:0) | ||
| 18:00 | Empoli FC | - | Borussia Dortmund | 3:5 (2:2) | ||
| 09.02.2022 | 13:00 | FC Midtjylland | - | Club Brugge KV | 3:2 (1:2) | |
| 16:00 | KRC Genk | - | Chelsea FC | 5:1 (1:0) | ||
| 18:00 | Hajduk Split | - | Atlético Madrid | 2:3 (0:0, 0:0) i.E. | ||
| 19:00 | Deportivo La Coruña | - | Dinamo Kiev | 2:3 (2:1, 2:2) i.E. |
