| Europa League | Sp. | S | U | N | Tore | |||
| Zu Hause | 1 | 0 | 1 | 0 | 1 | : | 1 | |
| Auswärts | 2 | 0 | 0 | 2 | 4 | : | 6 | |
| ∑ | 3 | 0 | 1 | 2 | 5 | : | 7 | |
| GESAMT | Sp. | S | U | N | Tore | |||
| Zu Hause | 1 | 0 | 1 | 0 | 1 | : | 1 | |
| Auswärts | 2 | 0 | 0 | 2 | 4 | : | 6 | |
| Neutraler Ort | 0 | 0 | 0 | 0 | 0 | : | 0 | |
| ∑ | 3 | 0 | 1 | 2 | 5 | : | 7 | |
| Europa League | |||||
| 2008/2009 | Gruppe A | Manchester City | - | FC Twente | 3:2 (1:1) |
| 1978/1979 | 1. Runde | Manchester City | - | FC Twente '65 | 3:2 (1:0) |
| 1978/1979 | 1. Runde | FC Twente '65 | - | Manchester City | 1:1 (0:1) |
|
Für Spiele, die im Elfmeterschießen entschieden wurden, geht der Spielstand nach 120 Minuten in diese Wertung ein. |
Niederlande 
![FC Twente [Frauen]](https://s.hs-data.com/bilder/wappen/mini/13616.gif?fallback=png "FC Twente [Frauen]"){kind=small}
![Twente/Heracles [U21]](https://s.hs-data.com/bilder/wappen/mini/34837.gif?fallback=png "Twente/Heracles [U21]"){kind=small}
![Twente/Heracles [U18]](https://s.hs-data.com/bilder/wappen/mini/34838.gif?fallback=png "Twente/Heracles [U18]"){kind=small}
![FC Twente [A-Junioren]](https://s.hs-data.com/bilder/wappen/mini/14623.gif?fallback=png "FC Twente [A-Junioren]"){kind=small}
![FC Twente [B-Junioren]](https://s.hs-data.com/bilder/wappen/mini/18987.gif?fallback=png "FC Twente [B-Junioren]"){kind=small}
![FC Twente [B-Juniorinnen]](https://s.hs-data.com/bilder/wappen/mini/35919.gif?fallback=png "FC Twente [B-Juniorinnen]"){kind=small}
![FC Twente [C-Junioren]](https://s.hs-data.com/bilder/wappen/mini/29047.gif?fallback=png "FC Twente [C-Junioren]"){kind=small}
