| 1. Spieltag | 25.09.1960 | AS Bari | - | AS Roma | 0:3 | ||||
| 2. Spieltag | 02.10.1960 | AS Roma | - | Udinese Calcio | 6:1 |  |
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| 3. Spieltag | 09.10.1960 | Torino FC | - | AS Roma | 1:3 | |
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| 4. Spieltag | 16.10.1960 | AS Roma | - | SPAL Ferrara | 2:1 | |
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| 5. Spieltag | 23.10.1960 | SSC Napoli | - | AS Roma | 3:2 | ||||
| 6. Spieltag | 06.11.1960 | AS Roma | - | Atalanta | 0:0 | ||||
| 7. Spieltag | 13.11.1960 | Lazio Roma | - | AS Roma | 0:4 | |
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| 8. Spieltag | 20.11.1960 | AS Roma | - | Calcio Padova | 3:1 | ||||
| 9. Spieltag | 27.11.1960 | AS Roma | - | Juventus | 2:1 | ||||
| 12. Spieltag | 25.12.1960 | Calcio Lecco 1912 | - | AS Roma | 0:0 | ||||
| 14. Spieltag | 08.01.1961 | AS Roma | - | Sampdoria | 3:2 | ||||
| 15. Spieltag | 15.01.1961 | Inter | - | AS Roma | 3:1 | ||||
| 18. Spieltag | 05.02.1961 | AS Roma | - | AS Bari | 1:0 | ||||
| 23. Spieltag | 12.03.1961 | Atalanta | - | AS Roma | 0:0 | ||||
| 24. Spieltag | 19.03.1961 | AS Roma | - | Lazio Roma | 1:2 | ||||
| 25. Spieltag | 26.03.1961 | Calcio Padova | - | AS Roma | 0:0 | ||||
| 27. Spieltag | 09.04.1961 | AS Roma | - | Calcio Catania | 4:1 | |
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| 28. Spieltag | 16.04.1961 | AC Milan | - | AS Roma | 2:1 | ||||
| 29. Spieltag | 30.04.1961 | AS Roma | - | Calcio Lecco 1912 | 1:0 | |
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| 30. Spieltag | 07.05.1961 | AS Roma | - | Bologna FC | 1:0 |
Italien