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| 18.03.2022 | 19:00 | 1. SC Feucht | - | Vatan Spor Aschaffenburg | 3:0 (3:0) | |
| 19:00 | DJK Gebenbach | - | ASV Neumarkt | 2:1 (1:1) | ||
| 19.03.2022 | 14:00 | SpVgg Ansbach | - | Eintracht Bamberg | 0:1 (0:0) | |
| 14:00 | TSV Abtswind | - | SpVgg Bayern Hof | 3:2 (2:1) | ||
| 14:00 | TSV Großbardorf | - | SV Seligenporten | 6:0 (1:0) | ||
| 14:00 | Würzburger FV | - | 1. FC Sand | 1:0 (0:0) | ||
| 16:00 | ASV Cham | - | DJK Bamberg | 0:0 (0:0) | ||
| 20.03.2022 | 14:00 | DJK Ammerthal | - | DJK Vilzing | 0:5 (0:2) | |
| 05.04.2022 | 19:00 | ATSV Erlangen | - | TSV Karlburg | 2:0 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Eintracht Bamberg | 25 | 18 | 4 | 3 | 67:19 | 48 | 58 |
| 2 |
|
ATSV Erlangen | 25 | 17 | 3 | 5 | 56:23 | 33 | 54 |
| 3 |
|
DJK Vilzing | 25 | 17 | 3 | 5 | 56:24 | 32 | 54 |
| 4 |
|
SpVgg Ansbach | 25 | 17 | 3 | 5 | 51:24 | 27 | 54 |
| 5 |
|
ASV Neumarkt | 25 | 14 | 4 | 7 | 51:33 | 18 | 46 |
| 6 |
|
DJK Bamberg | 25 | 13 | 4 | 8 | 43:38 | 5 | 43 |
| 7 |
|
DJK Ammerthal | 25 | 13 | 3 | 9 | 52:49 | 3 | 42 |
| 8 |
|
1. SC Feucht | 25 | 12 | 5 | 8 | 44:29 | 15 | 41 |
| 9 |
|
DJK Gebenbach | 25 | 11 | 4 | 10 | 55:47 | 8 | 37 |
| 10 |
|
TSV Abtswind | 25 | 11 | 2 | 12 | 35:38 | -3 | 35 |
| 11 |
|
SpVgg Bayern Hof | 25 | 9 | 4 | 12 | 46:51 | -5 | 31 |
| 12 |
|
TSV Großbardorf | 25 | 9 | 4 | 12 | 37:45 | -8 | 31 |
| 13 |
|
Würzburger FV | 25 | 6 | 6 | 13 | 28:49 | -21 | 24 |
| 14 |
|
TSV Karlburg | 25 | 3 | 11 | 11 | 16:40 | -24 | 20 |
| 15 |
|
ASV Cham | 25 | 5 | 4 | 16 | 35:60 | -25 | 19 |
| 16 |
|
1. FC Sand | 25 | 4 | 5 | 16 | 20:51 | -31 | 17 |
| 17 |
|
Vatan Spor Aschaffenburg | 25 | 3 | 6 | 16 | 24:55 | -31 | 15 |
| 18 |
|
SV Seligenporten | 25 | 4 | 3 | 18 | 30:71 | -41 | 15 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
