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| 20.02.2022 | 15:00 | BC Viktoria Glesch-Paffendorf | - | VfL 08 Vichttal | 2:1 (0:0) | |
| 15:00 | SV Bergisch Gladbach 09 | - | FC Hennef 05 | 1:0 (0:0) | ||
| 15:30 | Siegburger SV 04 | - | SV Deutz 05 | 1:2 (1:1) | ||
| 15:30 | Blau-Weiß Friesdorf | - | FC Hürth | 3:0 (1:0) | ||
| 27.02.2022 | 14:30 | Borussia Freialdenhoven | - | SpVg Frechen 20 | 1:1 (0:1) | |
| 03.03.2022 | 19:30 | Spvg Wesseling-Urfeld | - | VfL Alfter | 0:8 (0:5) | |
| 10.03.2022 | 19:30 | SV 1914 Eilendorf | - | Fortuna Köln II | 4:0 (3:0) | |
| 20:00 | SV Breinig | - | FC Pesch 1956 | 2:2 (0:1) | ||
| 20:00 | Viktoria Arnoldsweiler | - | 1. FC Düren | 1:1 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Düren | 18 | 13 | 4 | 1 | 48:12 | 36 | 43 |
| 2 |
|
SV Bergisch Gladbach 09 | 18 | 12 | 4 | 2 | 45:11 | 34 | 40 |
| 3 |
|
FC Hennef 05 | 18 | 12 | 3 | 3 | 41:13 | 28 | 39 |
| 4 |
|
SpVg Frechen 20 | 18 | 11 | 4 | 3 | 40:17 | 23 | 37 |
| 5 |
|
Siegburger SV 04 | 18 | 9 | 5 | 4 | 33:20 | 13 | 32 |
| 6 |
|
Borussia Freialdenhoven | 18 | 9 | 3 | 6 | 30:25 | 5 | 30 |
| 7 |
|
Viktoria Arnoldsweiler | 18 | 9 | 2 | 7 | 33:24 | 9 | 29 |
| 8 |
|
FC Pesch 1956 | 18 | 7 | 7 | 4 | 38:22 | 16 | 28 |
| 9 |
|
BC Viktoria Glesch-Paffendorf | 18 | 8 | 4 | 6 | 33:22 | 11 | 28 |
| 10 |
|
VfL Alfter | 18 | 8 | 3 | 7 | 32:32 | 0 | 27 |
| 11 |
|
Blau-Weiß Friesdorf | 18 | 7 | 5 | 6 | 29:30 | -1 | 26 |
| 12 |
|
VfL 08 Vichttal | 18 | 7 | 3 | 8 | 34:37 | -3 | 24 |
| 13 |
|
FC Hürth | 18 | 6 | 3 | 9 | 24:38 | -14 | 21 |
| 14 |
|
SV 1914 Eilendorf | 18 | 4 | 2 | 12 | 18:38 | -20 | 14 |
| 15 |
|
SV Deutz 05 | 18 | 3 | 2 | 13 | 16:44 | -28 | 11 |
| 16 |
|
Fortuna Köln II | 18 | 2 | 4 | 12 | 18:41 | -23 | 10 |
| 17 |
|
Spvg Wesseling-Urfeld | 18 | 3 | 0 | 15 | 16:65 | -49 | 9 |
| 18 |
|
SV Breinig | 18 | 2 | 2 | 14 | 19:56 | -37 | 8 |
| Playoffs | |
| Abstieg |
