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| 20.02.2022 | 14:00 | 1. FC Kaiserslautern II | - | Eintracht Trier | 2:1 (2:0) | |
| 14:00 | FSV Salmrohr | - | TuS Koblenz | 1:0 (1:0) | ||
| 26.02.2022 | 15:00 | FC Karbach | - | FV Engers 07 | 1:2 (0:0) | |
| 15:30 | SV Gonsenheim | - | SG Mülheim-Kärlich | 3:0 (3:0) | ||
| 16:00 | Sportfreunde Eisbachtal | - | TSV Emmelshausen | 1:2 (0:1) | ||
| 09.03.2022 | 19:30 | Hassia Bingen | - | SV Alemannia Waldalgesheim | 4:3 (0:3) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Eintracht Trier | 21 | 14 | 4 | 3 | 54:19 | 35 | 46 |
| 2 |
|
FV Engers 07 | 21 | 11 | 4 | 6 | 33:26 | 7 | 37 |
| 3 |
|
FC Karbach | 21 | 11 | 3 | 7 | 45:30 | 15 | 36 |
| 4 |
|
SV Alemannia Waldalgesheim | 21 | 11 | 3 | 7 | 39:32 | 7 | 36 |
| 5 |
|
SV Gonsenheim | 21 | 10 | 5 | 6 | 38:25 | 13 | 35 |
| 6 |
|
1. FC Kaiserslautern II | 21 | 8 | 5 | 8 | 32:38 | -6 | 29 |
| 7 |
|
TuS Koblenz | 21 | 7 | 5 | 9 | 29:30 | -1 | 26 |
| 8 |
|
SG Mülheim-Kärlich | 21 | 7 | 5 | 9 | 27:34 | -7 | 26 |
| 9 |
|
Sportfreunde Eisbachtal | 21 | 5 | 8 | 8 | 39:40 | -1 | 23 |
| 10 |
|
FSV Salmrohr | 21 | 7 | 1 | 13 | 29:55 | -26 | 22 |
| 11 |
|
Hassia Bingen | 21 | 5 | 4 | 12 | 27:38 | -11 | 19 |
| 12 |
|
TSV Emmelshausen | 21 | 5 | 3 | 13 | 17:42 | -25 | 18 |
| Playoffs | |
| Relegation |
