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| 25.04.2006 | 18:30 | Germania Ober-Roden | - | FSV Steinbach | 1:4 | |
| 18:30 | TSG Wattenbach | - | Bayern Alzenau | 1:1 | ||
| 18:30 | Viktoria Aschaffenburg | - | KSV Baunatal | 0:2 | ||
| 18:30 | SV Buchonia Flieden | - | Eintracht Frankfurt II | 1:3 | ||
| 18:30 | TSG Wörsdorf | - | SV Erzhausen | 0:1 | ||
| 26.04.2006 | 18:30 | Hessen Kassel | - | FV Bad Vilbel | 4:0 | |
| 18:30 | 1. FC Schwalmstadt | - | OSC Vellmar | 1:0 | ||
| 18:30 | FSV Frankfurt | - | SG Bruchköbel | 4:0 | ||
| 19:30 | KSV Klein-Karben | - | SC Waldgirmes | 0:2 |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FSV Frankfurt | 24 | 17 | 4 | 3 | 55:17 | 38 | 55 |
| 2 |
|
Hessen Kassel | 24 | 15 | 4 | 5 | 51:22 | 29 | 49 |
| 3 |
|
SC Waldgirmes | 24 | 13 | 8 | 3 | 42:26 | 16 | 47 |
| 4 |
|
SV Buchonia Flieden | 24 | 13 | 5 | 6 | 33:22 | 11 | 44 |
| 5 |
|
KSV Klein-Karben | 24 | 10 | 5 | 9 | 36:30 | 6 | 35 |
| 6 |
|
OSC Vellmar | 24 | 11 | 2 | 11 | 41:40 | 1 | 35 |
| 7 |
|
Bayern Alzenau | 24 | 10 | 5 | 9 | 31:34 | -3 | 35 |
| 8 |
|
KSV Baunatal | 24 | 9 | 6 | 9 | 30:37 | -7 | 33 |
| 9 |
|
FV Bad Vilbel | 24 | 8 | 8 | 8 | 32:34 | -2 | 32 |
| 10 |
|
SV Erzhausen | 24 | 9 | 5 | 10 | 34:37 | -3 | 32 |
| 11 |
|
TSG Wörsdorf | 24 | 8 | 7 | 9 | 34:31 | 3 | 31 |
| 12 |
|
1. FC Schwalmstadt | 24 | 9 | 4 | 11 | 32:41 | -9 | 31 |
| 13 |
|
Viktoria Aschaffenburg | 24 | 8 | 5 | 11 | 34:35 | -1 | 29 |
| 14 |
|
FSV Steinbach | 24 | 8 | 5 | 11 | 25:34 | -9 | 29 |
| 15 |
|
Eintracht Frankfurt II | 24 | 6 | 9 | 9 | 32:30 | 2 | 27 |
| 16 |
|
SG Bruchköbel | 24 | 7 | 5 | 12 | 32:43 | -11 | 26 |
| 17 |
|
Germania Ober-Roden | 24 | 7 | 3 | 14 | 33:56 | -23 | 24 |
| 18 |
|
TSG Wattenbach | 24 | 2 | 2 | 20 | 19:57 | -38 | 8 |
