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| 06.11.2021 | 20:00 | SV Deutz 05 | - | Blau-Weiß Friesdorf | 1:2 (0:1) | |
| 07.11.2021 | 14:30 | SV Breinig | - | Siegburger SV 04 | 1:4 (1:1) | |
| 14:30 | Spvg Wesseling-Urfeld | - | VfL 08 Vichttal | 2:4 (1:4) | ||
| 14:30 | BC Viktoria Glesch-Paffendorf | - | Viktoria Arnoldsweiler | 0:2 (0:2) | ||
| 14:30 | 1. FC Düren | - | Borussia Freialdenhoven | 2:0 (0:0) | ||
| 14:30 | VfL Alfter | - | SV Bergisch Gladbach 09 | 0:5 (0:4) | ||
| 15:00 | FC Pesch 1956 | - | SV 1914 Eilendorf | 3:1 (2:0) | ||
| 15:30 | Fortuna Köln II | - | SpVg Frechen 20 | 1:1 (1:1) | ||
| 24.11.2021 | 19:30 | FC Hennef 05 | - | FC Hürth | 2:0 Wert. |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Düren | 14 | 11 | 2 | 1 | 44:11 | 33 | 35 |
| 2 |
|
FC Hennef 05 | 14 | 10 | 3 | 1 | 32:8 | 24 | 33 |
| 3 |
|
SV Bergisch Gladbach 09 | 14 | 9 | 4 | 1 | 40:9 | 31 | 31 |
| 4 |
|
SpVg Frechen 20 | 14 | 9 | 3 | 2 | 30:11 | 19 | 30 |
| 5 |
|
Siegburger SV 04 | 14 | 8 | 4 | 2 | 25:12 | 13 | 28 |
| 6 |
|
Borussia Freialdenhoven | 14 | 8 | 1 | 5 | 24:17 | 7 | 25 |
| 7 |
|
Viktoria Arnoldsweiler | 14 | 7 | 1 | 6 | 26:21 | 5 | 22 |
| 8 |
|
FC Pesch 1956 | 14 | 5 | 6 | 3 | 28:16 | 12 | 21 |
| 9 |
|
VfL 08 Vichttal | 14 | 6 | 3 | 5 | 25:25 | 0 | 21 |
| 10 |
|
VfL Alfter | 14 | 6 | 3 | 5 | 22:27 | -5 | 21 |
| 11 |
|
FC Hürth | 14 | 6 | 2 | 6 | 22:28 | -6 | 20 |
| 12 |
|
Blau-Weiß Friesdorf | 14 | 5 | 4 | 5 | 23:26 | -3 | 19 |
| 13 |
|
BC Viktoria Glesch-Paffendorf | 14 | 5 | 3 | 6 | 19:18 | 1 | 18 |
| 14 |
|
Spvg Wesseling-Urfeld | 14 | 3 | 0 | 11 | 15:43 | -28 | 9 |
| 15 |
|
SV Deutz 05 | 14 | 2 | 2 | 10 | 14:35 | -21 | 8 |
| 16 |
|
Fortuna Köln II | 14 | 1 | 4 | 9 | 12:30 | -18 | 7 |
| 17 |
|
SV 1914 Eilendorf | 14 | 1 | 2 | 11 | 10:36 | -26 | 5 |
| 18 |
|
SV Breinig | 14 | 0 | 1 | 13 | 9:47 | -38 | 1 |
| Playoffs | |
| Abstieg |
