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| 13.11.2021 | 18:00 | Blau-Weiß Friesdorf | - | 1. FC Düren | 0:0 (0:0) | |
| 14.11.2021 | 14:30 | Spvg Wesseling-Urfeld | - | SV Breinig | 1:4 (0:3) | |
| 14:30 | Borussia Freialdenhoven | - | Fortuna Köln II | 4:2 (2:1) | ||
| 14:30 | SV Bergisch Gladbach 09 | - | SV Deutz 05 | 2:0 (2:0) | ||
| 14:30 | Viktoria Arnoldsweiler | - | FC Pesch 1956 | 1:0 (0:0) | ||
| 15:00 | SV 1914 Eilendorf | - | VfL Alfter | 2:0 (1:0) | ||
| 15:00 | Siegburger SV 04 | - | BC Viktoria Glesch-Paffendorf | 2:2 (2:1) | ||
| 15:15 | SpVg Frechen 20 | - | FC Hennef 05 | 2:4 (0:2) | ||
| 15:30 | VfL 08 Vichttal | - | FC Hürth | 5:1 (2:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Düren | 15 | 11 | 3 | 1 | 44:11 | 33 | 36 |
| 2 |
|
FC Hennef 05 | 15 | 11 | 3 | 1 | 36:10 | 26 | 36 |
| 3 |
|
SV Bergisch Gladbach 09 | 15 | 10 | 4 | 1 | 42:9 | 33 | 34 |
| 4 |
|
SpVg Frechen 20 | 15 | 9 | 3 | 3 | 32:15 | 17 | 30 |
| 5 |
|
Siegburger SV 04 | 15 | 8 | 5 | 2 | 27:14 | 13 | 29 |
| 6 |
|
Borussia Freialdenhoven | 15 | 9 | 1 | 5 | 28:19 | 9 | 28 |
| 7 |
|
Viktoria Arnoldsweiler | 15 | 8 | 1 | 6 | 27:21 | 6 | 25 |
| 8 |
|
VfL 08 Vichttal | 15 | 7 | 3 | 5 | 30:26 | 4 | 24 |
| 9 |
|
FC Pesch 1956 | 15 | 5 | 6 | 4 | 28:17 | 11 | 21 |
| 10 |
|
VfL Alfter | 15 | 6 | 3 | 6 | 22:29 | -7 | 21 |
| 11 |
|
Blau-Weiß Friesdorf | 15 | 5 | 5 | 5 | 23:26 | -3 | 20 |
| 12 |
|
FC Hürth | 15 | 6 | 2 | 7 | 23:33 | -10 | 20 |
| 13 |
|
BC Viktoria Glesch-Paffendorf | 15 | 5 | 4 | 6 | 21:20 | 1 | 19 |
| 14 |
|
Spvg Wesseling-Urfeld | 15 | 3 | 0 | 12 | 16:47 | -31 | 9 |
| 15 |
|
SV Deutz 05 | 15 | 2 | 2 | 11 | 14:37 | -23 | 8 |
| 16 |
|
SV 1914 Eilendorf | 15 | 2 | 2 | 11 | 12:36 | -24 | 8 |
| 17 |
|
Fortuna Köln II | 15 | 1 | 4 | 10 | 14:34 | -20 | 7 |
| 18 |
|
SV Breinig | 15 | 1 | 1 | 13 | 13:48 | -35 | 4 |
| Playoffs | |
| Abstieg |
