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| 22.03.1981 | Sportfreunde Siegen | - | VfL Gevelsberg | 2:2 | ||
| Eintracht Recklinghausen | - | Hellweg Lütgendortmund | 2:0 | |||
| VfB Waltrop | - | TuS Schloß-Neuhaus | 0:0 | |||
| VfB Altena | - | SuS Hüsten 09 | 1:4 | |||
| Teutonia Lippstadt | - | STV Horst-Emscher | 0:0 | |||
| 1. FC Paderborn | - | VfB Rheine | 3:0 | |||
| SV Holzwickede | - | Westfalia Herne | 0:0 | |||
| Hammer SpVg | - | FC Gütersloh | 3:0 | |||
| DSC Wanne-Eickel | - | Bünder SV | 2:1 |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfB Rheine | 27 | 15 | 7 | 5 | 58:32 | 26 | 37:17 |
| 2 |
|
VfL Gevelsberg | 27 | 14 | 9 | 4 | 57:32 | 25 | 37:17 |
| 3 |
|
1. FC Paderborn | 27 | 16 | 4 | 7 | 51:31 | 20 | 36:18 |
| 4 |
|
FC Gütersloh | 27 | 14 | 6 | 7 | 50:31 | 19 | 34:20 |
| 5 |
|
Sportfreunde Siegen | 27 | 13 | 7 | 7 | 46:36 | 10 | 33:21 |
| 6 |
|
DSC Wanne-Eickel | 27 | 11 | 10 | 6 | 61:40 | 21 | 32:22 |
| 7 |
|
Hammer SpVg | 27 | 13 | 6 | 8 | 53:41 | 12 | 32:22 |
| 8 |
|
TuS Schloß-Neuhaus | 27 | 13 | 5 | 9 | 48:38 | 10 | 31:23 |
| 9 |
|
VfB Waltrop | 27 | 10 | 7 | 10 | 41:41 | 0 | 27:27 |
| 10 |
|
Westfalia Herne | 27 | 8 | 11 | 8 | 37:40 | -3 | 27:27 |
| 11 |
|
SuS Hüsten 09 | 27 | 8 | 9 | 10 | 34:39 | -5 | 25:29 |
| 12 |
|
Hellweg Lütgendortmund | 27 | 7 | 9 | 11 | 31:42 | -11 | 23:31 |
| 13 |
|
Teutonia Lippstadt | 27 | 7 | 8 | 12 | 42:42 | 0 | 22:32 |
| 14 |
|
Eintracht Recklinghausen | 27 | 5 | 9 | 13 | 37:59 | -22 | 19:35 |
| 15 |
|
VfB Altena | 27 | 5 | 9 | 13 | 29:56 | -27 | 19:35 |
| 16 |
|
STV Horst-Emscher | 27 | 6 | 7 | 14 | 30:63 | -33 | 19:35 |
| 17 |
|
Bünder SV | 27 | 6 | 6 | 15 | 34:56 | -22 | 18:36 |
| 18 |
|
SV Holzwickede | 27 | 3 | 9 | 15 | 28:48 | -20 | 15:39 |
