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| 05.04.1981 | Eintracht Recklinghausen | - | VfL Gevelsberg | 1:2 | ||
| SuS Hüsten 09 | - | Hellweg Lütgendortmund | 1:2 | |||
| VfB Altena | - | TuS Schloß-Neuhaus | 2:4 | |||
| 1. FC Paderborn | - | Teutonia Lippstadt | 1:0 | |||
| SV Holzwickede | - | STV Horst-Emscher | 3:1 | |||
| Hammer SpVg | - | VfB Rheine | 3:1 | |||
| Sportfreunde Siegen | - | Westfalia Herne | 3:3 | |||
| DSC Wanne-Eickel | - | FC Gütersloh | 6:2 | |||
| VfB Waltrop | - | Bünder SV | 2:1 |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfL Gevelsberg | 29 | 16 | 9 | 4 | 60:33 | 27 | 41:17 |
| 2 |
|
1. FC Paderborn | 29 | 17 | 4 | 8 | 54:34 | 20 | 38:20 |
| 3 |
|
VfB Rheine | 29 | 15 | 7 | 7 | 60:37 | 23 | 37:21 |
| 4 |
|
FC Gütersloh | 29 | 15 | 6 | 8 | 53:37 | 16 | 36:22 |
| 5 |
|
Hammer SpVg | 29 | 14 | 7 | 8 | 57:43 | 14 | 35:23 |
| 6 |
|
DSC Wanne-Eickel | 29 | 12 | 10 | 7 | 67:43 | 24 | 34:24 |
| 7 |
|
TuS Schloß-Neuhaus | 29 | 14 | 6 | 9 | 53:41 | 12 | 34:24 |
| 8 |
|
Sportfreunde Siegen | 29 | 13 | 8 | 8 | 49:40 | 9 | 34:24 |
| 9 |
|
VfB Waltrop | 29 | 11 | 8 | 10 | 46:45 | 1 | 30:28 |
| 10 |
|
Westfalia Herne | 29 | 8 | 13 | 8 | 41:44 | -3 | 29:29 |
| 11 |
|
SuS Hüsten 09 | 29 | 8 | 10 | 11 | 36:42 | -6 | 26:32 |
| 12 |
|
Hellweg Lütgendortmund | 29 | 8 | 10 | 11 | 36:46 | -10 | 26:32 |
| 13 |
|
Teutonia Lippstadt | 29 | 8 | 8 | 13 | 47:44 | 3 | 24:34 |
| 14 |
|
Eintracht Recklinghausen | 29 | 6 | 9 | 14 | 39:61 | -22 | 21:37 |
| 15 |
|
STV Horst-Emscher | 29 | 7 | 7 | 15 | 34:68 | -34 | 21:37 |
| 16 |
|
SV Holzwickede | 29 | 5 | 9 | 15 | 33:50 | -17 | 19:39 |
| 17 |
|
VfB Altena | 29 | 5 | 9 | 15 | 32:65 | -33 | 19:39 |
| 18 |
|
Bünder SV | 29 | 6 | 6 | 17 | 35:59 | -24 | 18:40 |
