 |
 |
|
|
| 20.02.2022 | 15:00 | TuS Erndtebrück | - | TuS Ennepetal | 3:2 (1:0) | |
| 15:00 | RSV Meinerzhagen | - | SG Finnentrop/Bamenohl | 2:4 (1:4) | ||
| 16:00 | SC Paderborn 07 II | - | 1. FC Kaan-Marienborn | 1:1 (0:1) | ||
| 17:00 | Preußen Münster II | - | Viktoria Clarholz | 2:0 (1:0) | ||
| 27.02.2022 | 15:30 | Westfalia Herne | - | ASC 09 Dortmund | 2:4 (2:3) | |
| 09.03.2022 | 19:30 | Westfalia Rhynern | - | Holzwickeder SC | 2:0 (0:0) | |
| 10.03.2022 | 19:30 | TuS Haltern | - | SV Schermbeck | 0:2 (0:1) | |
| 16.03.2022 | 19:30 | SpVgg Vreden | - | FCE Rheine | 0:3 (0:1) | |
| 17.03.2022 | 19:30 | Sportfreunde Siegen | - | TSG Sprockhövel | 1:2 (0:0) | |
| 23.03.2022 | 19:30 | FC Gütersloh | - | SG Wattenscheid 09 | 0:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Paderborn 07 II | 16 | 11 | 3 | 2 | 49:15 | 34 | 36 |
| 2 |
|
1. FC Kaan-Marienborn | 16 | 11 | 3 | 2 | 42:15 | 27 | 36 |
| 3 |
|
ASC 09 Dortmund | 17 | 10 | 3 | 4 | 40:29 | 11 | 33 |
| 4 |
|
SG Wattenscheid 09 | 16 | 10 | 3 | 3 | 30:19 | 11 | 33 |
| 5 |
|
FC Gütersloh | 16 | 9 | 4 | 3 | 24:11 | 13 | 31 |
| 6 |
|
Westfalia Rhynern | 16 | 10 | 0 | 6 | 45:21 | 24 | 30 |
| 7 |
|
TuS Erndtebrück | 16 | 8 | 4 | 4 | 33:29 | 4 | 28 |
| 8 |
|
FCE Rheine | 16 | 9 | 1 | 6 | 28:26 | 2 | 28 |
| 9 |
|
SV Schermbeck | 16 | 8 | 2 | 6 | 30:21 | 9 | 26 |
| 10 |
|
Sportfreunde Siegen | 17 | 6 | 6 | 5 | 27:29 | -2 | 24 |
| 11 |
|
TSG Sprockhövel | 16 | 7 | 2 | 7 | 36:27 | 9 | 23 |
| 12 |
|
Preußen Münster II | 16 | 5 | 4 | 7 | 27:34 | -7 | 19 |
| 13 |
|
SpVgg Vreden | 17 | 5 | 4 | 8 | 17:34 | -17 | 19 |
| 14 |
|
Hammer SpVg | 16 | 5 | 3 | 8 | 25:35 | -10 | 18 |
| 15 |
|
SG Finnentrop/Bamenohl | 16 | 3 | 7 | 6 | 28:38 | -10 | 16 |
| 16 |
|
TuS Ennepetal | 16 | 4 | 4 | 8 | 26:37 | -11 | 16 |
| 17 |
|
Viktoria Clarholz | 16 | 4 | 3 | 9 | 22:30 | -8 | 15 |
| 18 |
|
TuS Haltern | 16 | 4 | 3 | 9 | 21:29 | -8 | 15 |
| 19 |
|
Holzwickeder SC | 17 | 4 | 2 | 11 | 16:44 | -28 | 14 |
| 20 |
|
RSV Meinerzhagen | 16 | 4 | 0 | 12 | 25:45 | -20 | 12 |
| 21 |
|
Westfalia Herne | 16 | 1 | 3 | 12 | 18:41 | -23 | 6 |
| Playoffs | |
| Relegation |
