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| 19.09.2021 | 15:00 | Westfalia Rhynern | - | FCE Rheine | 3:0 (1:0) | |
| 15:00 | SC Paderborn 07 II | - | Sportfreunde Siegen | 3:1 (0:0) | ||
| 15:00 | TuS Erndtebrück | - | FC Gütersloh | 3:0 (2:0) | ||
| 15:00 | RSV Meinerzhagen | - | Hammer SpVg | 2:0 (1:0) | ||
| 15:00 | ASC 09 Dortmund | - | SV Schermbeck | 2:2 (2:0) | ||
| 15:00 | Preußen Münster II | - | SpVgg Vreden | 4:2 (2:2) | ||
| 15:00 | SG Finnentrop/Bamenohl | - | TuS Ennepetal | 3:3 (3:0) | ||
| 15:00 | 1. FC Kaan-Marienborn | - | Viktoria Clarholz | 3:3 (0:1) | ||
| 15:00 | Holzwickeder SC | - | SG Wattenscheid 09 | 1:3 (1:1) | ||
| 15:15 | Westfalia Herne | - | TSG Sprockhövel | 1:1 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SG Wattenscheid 09 | 4 | 4 | 0 | 0 | 12:6 | 6 | 12 |
| 2 |
|
SC Paderborn 07 II | 4 | 3 | 0 | 1 | 10:3 | 7 | 9 |
| 3 |
|
FCE Rheine | 4 | 3 | 0 | 1 | 4:4 | 0 | 9 |
| 4 |
|
1. FC Kaan-Marienborn | 3 | 2 | 1 | 0 | 12:4 | 8 | 7 |
| 5 |
|
TSG Sprockhövel | 4 | 2 | 1 | 1 | 9:6 | 3 | 7 |
| 6 |
|
TuS Ennepetal | 4 | 2 | 1 | 1 | 12:10 | 2 | 7 |
| 7 |
|
ASC 09 Dortmund | 4 | 2 | 1 | 1 | 11:9 | 2 | 7 |
| 8 |
|
Preußen Münster II | 4 | 2 | 1 | 1 | 8:6 | 2 | 7 |
| 9 |
|
Westfalia Rhynern | 4 | 2 | 0 | 2 | 11:6 | 5 | 6 |
| 10 |
|
Holzwickeder SC | 4 | 2 | 0 | 2 | 8:10 | -2 | 6 |
| 11 |
|
TuS Haltern | 3 | 1 | 2 | 0 | 3:1 | 2 | 5 |
| 12 |
|
TuS Erndtebrück | 4 | 1 | 2 | 1 | 7:8 | -1 | 5 |
| 13 |
|
SV Schermbeck | 4 | 1 | 1 | 2 | 10:9 | 1 | 4 |
| 14 |
|
FC Gütersloh | 3 | 1 | 1 | 1 | 2:3 | -1 | 4 |
| 15 |
|
Hammer SpVg | 4 | 1 | 0 | 3 | 7:9 | -2 | 3 |
| 16 |
|
RSV Meinerzhagen | 4 | 1 | 0 | 3 | 6:11 | -5 | 3 |
| 17 |
|
Viktoria Clarholz | 4 | 0 | 2 | 2 | 7:11 | -4 | 2 |
| 18 |
|
Sportfreunde Siegen | 4 | 0 | 2 | 2 | 4:8 | -4 | 2 |
|
SpVgg Vreden | 4 | 0 | 2 | 2 | 4:8 | -4 | 2 | |
| 20 |
|
SG Finnentrop/Bamenohl | 3 | 0 | 2 | 1 | 4:10 | -6 | 2 |
| 21 |
|
Westfalia Herne | 4 | 0 | 1 | 3 | 2:11 | -9 | 1 |
| Playoffs | |
| Relegation |
