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| 10.10.2021 | 15:00 | FC Gütersloh | - | RSV Meinerzhagen | 3:0 (2:0) | |
| 15:00 | TSG Sprockhövel | - | ASC 09 Dortmund | 3:3 (2:1) | ||
| 15:00 | Sportfreunde Siegen | - | Westfalia Rhynern | 0:3 (0:1) | ||
| 15:00 | SpVgg Vreden | - | Westfalia Herne | 3:2 (0:1) | ||
| 15:00 | FCE Rheine | - | SG Finnentrop/Bamenohl | 2:1 (1:0) | ||
| 15:00 | Hammer SpVg | - | Holzwickeder SC | 1:1 (0:1) | ||
| 15:00 | TuS Erndtebrück | - | Preußen Münster II | 2:0 (1:0) | ||
| 15:00 | TuS Haltern | - | SC Paderborn 07 II | 2:5 (0:2) | ||
| 15:00 | SV Schermbeck | - | Viktoria Clarholz | 1:0 (0:0) | ||
| 15:00 | SG Wattenscheid 09 | - | 1. FC Kaan-Marienborn | 0:1 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FCE Rheine | 7 | 6 | 0 | 1 | 10:5 | 5 | 18 |
| 2 |
|
SC Paderborn 07 II | 7 | 5 | 1 | 1 | 21:6 | 15 | 16 |
| 3 |
|
1. FC Kaan-Marienborn | 6 | 5 | 1 | 0 | 17:4 | 13 | 16 |
| 4 |
|
SG Wattenscheid 09 | 7 | 5 | 0 | 2 | 14:9 | 5 | 15 |
| 5 |
|
TSG Sprockhövel | 7 | 4 | 2 | 1 | 22:9 | 13 | 14 |
| 6 |
|
Westfalia Rhynern | 7 | 4 | 0 | 3 | 19:13 | 6 | 12 |
| 7 |
|
FC Gütersloh | 6 | 3 | 2 | 1 | 10:5 | 5 | 11 |
| 8 |
|
ASC 09 Dortmund | 7 | 3 | 2 | 2 | 16:13 | 3 | 11 |
| 9 |
|
SV Schermbeck | 7 | 3 | 1 | 3 | 15:11 | 4 | 10 |
| 10 |
|
TuS Ennepetal | 6 | 3 | 1 | 2 | 13:13 | 0 | 10 |
| 11 |
|
Preußen Münster II | 7 | 3 | 1 | 3 | 12:13 | -1 | 10 |
| 12 |
|
TuS Erndtebrück | 6 | 2 | 3 | 1 | 10:9 | 1 | 9 |
| 13 |
|
Sportfreunde Siegen | 7 | 2 | 2 | 3 | 9:12 | -3 | 8 |
| 14 |
|
SpVgg Vreden | 7 | 2 | 2 | 3 | 8:15 | -7 | 8 |
| 15 |
|
Hammer SpVg | 7 | 2 | 1 | 4 | 14:15 | -1 | 7 |
| 16 |
|
Holzwickeder SC | 7 | 2 | 1 | 4 | 9:19 | -10 | 7 |
| 17 |
|
TuS Haltern | 6 | 1 | 3 | 2 | 7:10 | -3 | 6 |
| 18 |
|
RSV Meinerzhagen | 7 | 1 | 0 | 6 | 7:18 | -11 | 3 |
| 19 |
|
Viktoria Clarholz | 6 | 0 | 2 | 4 | 7:13 | -6 | 2 |
| 20 |
|
SG Finnentrop/Bamenohl | 6 | 0 | 2 | 4 | 6:18 | -12 | 2 |
| 21 |
|
Westfalia Herne | 7 | 0 | 1 | 6 | 4:20 | -16 | 1 |
| Playoffs | |
| Relegation |
