H Dinamo Zagreb / Omonia Nikosia - Legia / FC Flora -:-
R Legia / FC Flora - Dinamo Zagreb / Omonia Nikosia -:-
H: 05.08.2021 R: 12.08.2021
H Lud. Razgrad / NŠ Mura - Ferencváros / FK Žalgiris -:-
R Ferencváros / FK Žalgiris - Lud. Razgrad / NŠ Mura -:-
H: 05.08.2021 R: 12.08.2021
H Crvena Zvezda / FK Kairat - FC Alashkert / FC Sheriff -:-
R FC Alashkert / FC Sheriff - Crvena Zvezda / FK Kairat -:-
H: 05.08.2021 R: 12.08.2021
H Cluj / Lincoln Red Imps - Young Boys / Slovan Bratislava -:-
R Young Boys / Slovan Bratislava - Cluj / Lincoln Red Imps -:-
H: 05.08.2021 R: 12.08.2021
H Olympiakos / Neftci - Malmö FF / HJK Helsinki -:-
R Malmö FF / HJK Helsinki - Olympiakos / Neftci -:-
H: 05.08.2021 R: 12.08.2021
H FK Jablonec - Celtic / Midtjylland -:-
R Celtic / Midtjylland - FK Jablonec -:-
H: 05.08.2021 R: 12.08.2021
H Sparta Praha / Rapid Wien - Anorthosis Famagusta -:-
R Anorthosis Famagusta - Sparta Praha / Rapid Wien -:-
H: 05.08.2021 R: 12.08.2021
H PSV / Galatasaray - St. Johnstone FC -:-
R St. Johnstone FC - PSV / Galatasaray -:-
H: 05.08.2021 R: 12.08.2021