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| 21.01.2022 | 20:45 | Hellas Verona | - | Bologna FC | 2:1 (1:1) | |
| 22.01.2022 | 15:00 | Genoa CFC | - | Udinese Calcio | 0:0 (0:0) | |
| 18:00 | Inter | - | Venezia FC | 2:1 (1:1) | ||
| 20:45 | Lazio Roma | - | Atalanta | 0:0 (0:0) | ||
| 23.01.2022 | 12:30 | Cagliari Calcio | - | ACF Fiorentina | 1:1 (0:0) | |
| 15:00 | Torino FC | - | Sassuolo Calcio | 1:1 (1:0) | ||
| 15:00 | Spezia Calcio | - | Sampdoria | 1:0 (0:0) | ||
| 15:00 | SSC Napoli | - | US Salernitana 1919 | 4:1 (2:1) | ||
| 18:00 | Empoli FC | - | AS Roma | 2:4 (0:4) | ||
| 20:45 | AC Milan | - | Juventus | 0:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Inter | 23 | 16 | 5 | 2 | 54:19 | 35 | 53 |
| 2 |
|
SSC Napoli | 23 | 15 | 4 | 4 | 43:16 | 27 | 49 |
| 3 |
|
AC Milan | 23 | 15 | 4 | 4 | 47:25 | 22 | 49 |
| 4 |
|
Atalanta | 23 | 12 | 8 | 3 | 48:30 | 18 | 44 |
| 5 |
|
Juventus | 23 | 12 | 6 | 5 | 34:21 | 13 | 42 |
| 6 |
|
AS Roma | 23 | 12 | 2 | 9 | 40:30 | 10 | 38 |
| 7 |
|
Lazio Roma | 23 | 10 | 6 | 7 | 46:39 | 7 | 36 |
| 8 |
|
ACF Fiorentina | 23 | 11 | 3 | 9 | 41:34 | 7 | 36 |
| 9 |
|
Torino FC | 23 | 9 | 6 | 8 | 34:25 | 9 | 33 |
| 10 |
|
Hellas Verona | 23 | 9 | 6 | 8 | 43:38 | 5 | 33 |
| 11 |
|
Bologna FC | 23 | 9 | 3 | 11 | 31:38 | -7 | 30 |
| 12 |
|
Sassuolo Calcio | 23 | 7 | 8 | 8 | 39:38 | 1 | 29 |
| 13 |
|
Empoli FC | 23 | 8 | 5 | 10 | 37:47 | -10 | 29 |
| 14 |
|
Spezia Calcio | 23 | 7 | 4 | 12 | 24:42 | -18 | 25 |
| 15 |
|
Udinese Calcio | 23 | 5 | 9 | 9 | 32:37 | -5 | 24 |
| 16 |
|
Sampdoria | 23 | 5 | 5 | 13 | 29:41 | -12 | 20 |
| 17 |
|
Venezia FC | 23 | 4 | 6 | 13 | 21:42 | -21 | 18 |
| 18 |
|
Cagliari Calcio | 23 | 3 | 8 | 12 | 22:44 | -22 | 17 |
| 19 |
|
US Salernitana 1919 | 23 | 5 | 2 | 16 | 17:51 | -34 | 17 |
| 20 |
|
Genoa CFC | 23 | 1 | 10 | 12 | 20:45 | -25 | 13 |
| Champions League | |
| Europa League | |
| Europa Conference League Quali. | |
| Abstieg |
