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| 20.02.2021 | 14:00 | Bahlinger SC | - | TSG Balingen | 2:0 (2:0) | |
| 14:00 | FC 08 Homburg | - | TSV Schott Mainz | 2:1 (2:1) | ||
| 14:00 | Bayern Alzenau | - | FC-Astoria Walldorf | 0:2 (0:1) | ||
| 14:00 | 1. FSV Mainz 05 II | - | TSV Steinbach Haiger | 1:1 (0:1) | ||
| 14:00 | Kickers Offenbach | - | FK Pirmasens | 1:0 (1:0) | ||
| 14:00 | Rot-Weiß Koblenz | - | FC Gießen | 1:1 (0:1) | ||
| 14:00 | SG Sonnenhof Großaspach | - | 1899 Hoffenheim II | 3:3 (0:1) | ||
| 14:00 | SV 07 Elversberg | - | VfB Stuttgart II | 4:0 (1:0) | ||
| 14:00 | VfR Aalen | - | SC Freiburg II | 1:3 (0:2) | ||
| 21.02.2021 | 14:00 | Hessen Kassel | - | Eintracht Stadtallendorf | 3:1 (1:0) | |
| 23.03.2021 | 19:00 | FSV Frankfurt | - | SSV Ulm 1846 | 1:3 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 24 | 15 | 6 | 3 | 60:27 | 33 | 51 |
| 2 |
|
Kickers Offenbach | 24 | 12 | 9 | 3 | 42:15 | 27 | 45 |
| 3 |
|
TSV Steinbach Haiger | 24 | 13 | 6 | 5 | 48:28 | 20 | 45 |
| 4 |
|
FSV Frankfurt | 24 | 13 | 6 | 5 | 37:26 | 11 | 45 |
| 5 |
|
SSV Ulm 1846 | 24 | 12 | 7 | 5 | 46:23 | 23 | 43 |
| 6 |
|
SV 07 Elversberg | 24 | 11 | 9 | 4 | 51:28 | 23 | 42 |
| 7 |
|
VfB Stuttgart II | 24 | 10 | 6 | 8 | 48:30 | 18 | 36 |
| 8 |
|
Bahlinger SC | 24 | 10 | 6 | 8 | 39:45 | -6 | 36 |
| 9 |
|
FC 08 Homburg | 24 | 9 | 8 | 7 | 44:35 | 9 | 35 |
| 10 |
|
TSG Balingen | 24 | 10 | 5 | 9 | 36:32 | 4 | 35 |
| 11 |
|
1. FSV Mainz 05 II | 24 | 8 | 7 | 9 | 31:35 | -4 | 31 |
| 12 |
|
Rot-Weiß Koblenz | 24 | 8 | 6 | 10 | 27:35 | -8 | 30 |
| 13 |
|
Hessen Kassel | 24 | 7 | 8 | 9 | 34:42 | -8 | 29 |
| 14 |
|
FK Pirmasens | 24 | 7 | 8 | 9 | 22:38 | -16 | 29 |
| 15 |
|
FC Gießen | 24 | 7 | 7 | 10 | 25:31 | -6 | 28 |
| 16 |
|
VfR Aalen | 24 | 7 | 7 | 10 | 28:38 | -10 | 28 |
| 17 |
|
SG Sonnenhof Großaspach | 24 | 7 | 6 | 11 | 32:40 | -8 | 27 |
| 18 |
|
1899 Hoffenheim II | 24 | 7 | 5 | 12 | 32:46 | -14 | 26 |
| 19 |
|
FC-Astoria Walldorf | 24 | 7 | 4 | 13 | 30:41 | -11 | 25 |
| 20 |
|
TSV Schott Mainz | 24 | 7 | 4 | 13 | 34:58 | -24 | 25 |
| 21 |
|
Bayern Alzenau | 24 | 5 | 6 | 13 | 28:47 | -19 | 21 |
| 22 |
|
Eintracht Stadtallendorf | 24 | 1 | 6 | 17 | 20:54 | -34 | 9 |
| Aufstieg | |
| Abstieg |
