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| 17.04.2021 | 14:00 | Bahlinger SC | - | Eintracht Stadtallendorf | 1:0 (0:0) | |
| 14:00 | FC-Astoria Walldorf | - | SV 07 Elversberg | 1:4 (0:1) | ||
| 14:00 | FSV Frankfurt | - | Rot-Weiß Koblenz | 1:2 (1:2) | ||
| 14:00 | 1. FSV Mainz 05 II | - | Hessen Kassel | 2:1 (2:0) | ||
| 14:00 | Kickers Offenbach | - | VfB Stuttgart II | 1:1 (0:0) | ||
| 14:00 | SC Freiburg II | - | FK Pirmasens | 1:0 (0:0) | ||
| 14:00 | SG Sonnenhof Großaspach | - | TSV Schott Mainz | 1:4 (0:1) | ||
| 14:00 | 1899 Hoffenheim II | - | FC Gießen | 2:2 (2:0) | ||
| 14:00 | TSV Steinbach Haiger | - | Bayern Alzenau | 4:0 (1:0) | ||
| 14:00 | VfR Aalen | - | FC 08 Homburg | 1:1 (0:0) | ||
| 11.05.2021 | 19:00 | TSG Balingen | - | SSV Ulm 1846 | 0:4 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 32 | 21 | 7 | 4 | 74:32 | 42 | 70 |
| 2 |
|
SSV Ulm 1846 | 32 | 18 | 8 | 6 | 61:27 | 34 | 62 |
| 3 |
|
Kickers Offenbach | 32 | 17 | 11 | 4 | 52:22 | 30 | 62 |
| 4 |
|
SV 07 Elversberg | 32 | 16 | 12 | 4 | 73:34 | 39 | 60 |
| 5 |
|
TSV Steinbach Haiger | 32 | 17 | 9 | 6 | 65:32 | 33 | 60 |
| 6 |
|
FSV Frankfurt | 32 | 16 | 8 | 8 | 44:34 | 10 | 56 |
| 7 |
|
Bahlinger SC | 32 | 14 | 7 | 11 | 49:56 | -7 | 49 |
| 8 |
|
FC 08 Homburg | 32 | 12 | 12 | 8 | 55:43 | 12 | 48 |
| 9 |
|
VfB Stuttgart II | 32 | 13 | 7 | 12 | 58:40 | 18 | 46 |
| 10 |
|
Rot-Weiß Koblenz | 32 | 12 | 8 | 12 | 39:42 | -3 | 44 |
| 11 |
|
1. FSV Mainz 05 II | 32 | 12 | 8 | 12 | 46:50 | -4 | 44 |
| 12 |
|
TSG Balingen | 32 | 11 | 8 | 13 | 41:43 | -2 | 41 |
| 13 |
|
VfR Aalen | 32 | 10 | 11 | 11 | 35:43 | -8 | 41 |
| 14 |
|
Hessen Kassel | 32 | 10 | 9 | 13 | 44:56 | -12 | 39 |
| 15 |
|
FK Pirmasens | 32 | 8 | 13 | 11 | 29:47 | -18 | 37 |
| 16 |
|
FC Gießen | 32 | 8 | 12 | 12 | 33:39 | -6 | 36 |
| 17 |
|
1899 Hoffenheim II | 32 | 9 | 8 | 15 | 42:59 | -17 | 35 |
| 18 |
|
SG Sonnenhof Großaspach | 32 | 8 | 10 | 14 | 40:56 | -16 | 34 |
| 19 |
|
TSV Schott Mainz | 32 | 9 | 5 | 18 | 44:75 | -31 | 32 |
| 20 |
|
FC-Astoria Walldorf | 32 | 9 | 4 | 19 | 43:58 | -15 | 31 |
| 21 |
|
Bayern Alzenau | 32 | 5 | 7 | 20 | 38:69 | -31 | 22 |
| 22 |
|
Eintracht Stadtallendorf | 32 | 2 | 6 | 24 | 26:74 | -48 | 12 |
| Aufstieg | |
| Abstieg |
