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| 04.05.2021 | 14:00 | SC Freiburg II | - | VfB Stuttgart II | 3:1 (2:0) | |
| 18:00 | Bahlinger SC | - | Rot-Weiß Koblenz | 2:1 (1:0) | ||
| 18:00 | Bayern Alzenau | - | FC Gießen | 1:1 (1:1) | ||
| 18:00 | TSG Balingen | - | Eintracht Stadtallendorf | 0:4 (0:1) | ||
| 19:00 | 1. FSV Mainz 05 II | - | FSV Frankfurt | 1:3 (0:2) | ||
| 19:00 | SG Sonnenhof Großaspach | - | SV 07 Elversberg | 1:2 (0:0) | ||
| 19:00 | FK Pirmasens | - | SSV Ulm 1846 | 0:2 (0:0) | ||
| 19:00 | TSV Steinbach Haiger | - | TSV Schott Mainz | 4:0 (0:0) | ||
| 19:00 | VfR Aalen | - | FC-Astoria Walldorf | 2:1 (0:1) | ||
| 19:00 | Kickers Offenbach | - | FC 08 Homburg | 3:2 (2:2) | ||
| 19:00 | 1899 Hoffenheim II | - | Hessen Kassel | 1:1 (0:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 36 | 25 | 7 | 4 | 85:35 | 50 | 82 |
| 2 |
|
Kickers Offenbach | 36 | 21 | 11 | 4 | 67:26 | 41 | 74 |
| 3 |
|
SV 07 Elversberg | 36 | 20 | 12 | 4 | 86:40 | 46 | 72 |
| 4 |
|
TSV Steinbach Haiger | 36 | 20 | 9 | 7 | 75:34 | 41 | 69 |
| 5 |
|
SSV Ulm 1846 | 36 | 20 | 9 | 7 | 65:31 | 34 | 69 |
| 6 |
|
FSV Frankfurt | 36 | 18 | 8 | 10 | 49:40 | 9 | 62 |
| 7 |
|
FC 08 Homburg | 36 | 14 | 13 | 9 | 63:50 | 13 | 55 |
| 8 |
|
Bahlinger SC | 36 | 15 | 8 | 13 | 56:64 | -8 | 53 |
| 9 |
|
VfB Stuttgart II | 36 | 15 | 7 | 14 | 64:46 | 18 | 52 |
| 10 |
|
Rot-Weiß Koblenz | 36 | 13 | 10 | 13 | 46:49 | -3 | 49 |
| 11 |
|
VfR Aalen | 36 | 12 | 12 | 12 | 41:47 | -6 | 48 |
| 12 |
|
1. FSV Mainz 05 II | 36 | 12 | 10 | 14 | 52:62 | -10 | 46 |
| 13 |
|
Hessen Kassel | 36 | 11 | 11 | 14 | 49:64 | -15 | 44 |
| 14 |
|
1899 Hoffenheim II | 36 | 11 | 9 | 16 | 49:64 | -15 | 42 |
| 15 |
|
TSG Balingen | 36 | 11 | 8 | 17 | 43:55 | -12 | 41 |
| 16 |
|
FC Gießen | 36 | 9 | 13 | 14 | 38:46 | -8 | 40 |
| 17 |
|
FK Pirmasens | 36 | 9 | 13 | 14 | 34:54 | -20 | 40 |
| 18 |
|
FC-Astoria Walldorf | 36 | 11 | 4 | 21 | 51:64 | -13 | 37 |
| 19 |
|
SG Sonnenhof Großaspach | 36 | 9 | 10 | 17 | 46:63 | -17 | 37 |
| 20 |
|
TSV Schott Mainz | 36 | 10 | 5 | 21 | 49:87 | -38 | 35 |
| 21 |
|
Bayern Alzenau | 36 | 5 | 9 | 22 | 42:78 | -36 | 24 |
| 22 |
|
Eintracht Stadtallendorf | 36 | 3 | 6 | 27 | 31:82 | -51 | 15 |
| Aufstieg | |
| Abstieg |
