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| 11.11.2020 | 12:00 | AZ Alkmaar | - | AFC Ajax | 3:4 (1:1) | |
| 13:00 | SV Darmstadt 98 | - | Jahn Regensburg | 3:3 | ||
| 13:00 | Vitesse | - | sc Heerenveen | 3:1 (0:0) | ||
| 12.11.2020 | 1. FC Union Berlin | - | Eintracht Braunschweig | n.gesp. | ||
| 13:00 | FC Twente | - | PEC Zwolle | 3:0 (3:0) | ||
| 14:00 | Eintracht Frankfurt | - | 1. FC Nürnberg | 0:2 (0:0) | ||
| 14:00 | RKC Waalwijk | - | FC Utrecht | 4:3 (0:2) | ||
| 14:30 | Feyenoord | - | ADO Den Haag | 0:0 (0:0) | ||
| 15:00 | 1. FC Köln | - | VfL Bochum | 1:3 (0:1) | ||
| 15:00 | Hamburger SV | - | Viborg FF | 1:3 | ||
| 13.11.2020 | 11:00 | KV Oostende | - | USL Dunkerque | 2:1 | |
| 14:00 | Werder Bremen | - | FC St. Pauli | 2:4 (0:2) | ||
| 15:00 | VfB Stuttgart | - | 1. FC Heidenheim 1846 | 1:0 (0:0) | ||
| 15:00 | Inter | - | AC Monza | 1:0 (0:0) | ||
| 15:00 | AS Saint-Étienne | - | Grenoble Foot 38 | 3:2 (1:2) | ||
| 14.11.2020 | 12:00 | Hannover 96 | - | VfL Wolfsburg | 0:0 (0:0) |
