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| H | Juventus | - | Tottenham Hotspur | 2:2 (2:1) | ||
| R | Tottenham Hotspur | - | Juventus | 1:2 (1:0) | ||
| H: 13.02.2018 20:45 | R: 07.03.2018 20:45 | Sieger: Juventus | ||||
| H | FC Basel 1893 | - | Manchester City | 0:4 (0:3) | ||
| R | Manchester City | - | FC Basel 1893 | 1:2 (1:1) | ||
| H: 13.02.2018 20:45 | R: 07.03.2018 20:45 | Sieger: Manchester City | ||||
| H | FC Porto | - | Liverpool FC | 0:5 (0:2) | ||
| R | Liverpool FC | - | FC Porto | 0:0 (0:0) | ||
| H: 14.02.2018 20:45 | R: 06.03.2018 20:45 | Sieger: Liverpool FC | ||||
| H | Real Madrid | - | Paris Saint-Germain | 3:1 (1:1) | ||
| R | Paris Saint-Germain | - | Real Madrid | 1:2 (0:0) | ||
| H: 14.02.2018 20:45 | R: 06.03.2018 20:45 | Sieger: Real Madrid | ||||
| H | Chelsea FC | - | FC Barcelona | 1:1 (0:0) | ||
| R | FC Barcelona | - | Chelsea FC | 3:0 (2:0) | ||
| H: 20.02.2018 20:45 | R: 14.03.2018 20:45 | Sieger: FC Barcelona | ||||
| H | Bayern München | - | Beşiktaş | 5:0 (1:0) | ||
| R | Beşiktaş | - | Bayern München | 1:3 (0:1) | ||
| H: 20.02.2018 20:45 | R: 14.03.2018 18:00 | Sieger: Bayern München | ||||
| H | Sevilla FC | - | Manchester United | 0:0 (0:0) | ||
| R | Manchester United | - | Sevilla FC | 1:2 (0:0) | ||
| H: 21.02.2018 20:45 | R: 13.03.2018 20:45 | Sieger: Sevilla FC | ||||
| H | Shakhtar Donetsk | - | AS Roma | 2:1 (0:1) | ||
| R | AS Roma | - | Shakhtar Donetsk | 1:0 (0:0) | ||
| H: 21.02.2018 20:45 | R: 13.03.2018 20:45 | Sieger: AS Roma | ||||
